We all know what alc0h0l can do to your body. In the short term, it makes you drunk, and in the slightly longer term, it makes you hungover. But what even longer term effects does drinking too much alc0h0l have on your body?

There are obvious negative effects of alc0h0l, like liver problems, skin problems, and circulation problems, not to mention weight gain and a decrease in motor functions. But what are the other ways alc0h0l hurts? Ibrahim Hanouneh, MD, who works in gastroenterology and hepatology at the Cleveland Clinic, shares some lesser-known problems associated with alc0h0l consumption.

1. Alc0h0l takes priority. When you consume any alc0h0l, your body makes breaking down the alc0h0l its top priority. Your body cannot store alc0h0l (like with proteins, carbs, and fats), so your liver works extra hard to detoxify your entire body by removing the alc0h0l from the blood. This slows down and confuses the body which is why you get drunk, and because your liver has to work so hard, it is more likely to be problematic later.

2. Bacteria grows in your gut. Alc0h0l abuse often leads to intestinal bacteria growth. These bacteria can migrate through the intestinal wall. This is problematic on its own, but when the bacteria gets into the liver it can cause serious damage. Even a single night of drinking can damage the intestinal lining.

3. Your heart will become weakened. Drinking too much alc0h0l can lead to a weak heart (cardiomyopathy), irregular patterns (arrhythmia), or high blood pressure.

A study shows that alc0h0lism and depression are also heavily connected. leads to drinking, or drinking leads to depression is still not .

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4. You’ll develop pancreatitis. Your pancreas produces insulin, which allows the food you eat to be used as energy. Pancreatitis is an inflammation in the pancreas, where it becomes inflamed and starts to slow down insulin production. Pancreatitis typically brings high blood pressure and can even cause malabsorption syndrome and diabetes.

5. Risk for cancer. Cancer of the mouth, esophagus, throat, breast, and, of course, liver, have been associated with alc0h0lism.

6. A stressed immune system. Drinking alc0h0l, especially binge drinking, stresses your entire system. A stressed immune system opens the body to infection, disease, and worse.

Doctors suggest drinking red wine can be good for you, but I would still take caution. Dr. Hanouneh says healthy people can still drink, but certainly not every day, or even most days of the week. All this said, alc0h0l is best avoided, but can be fine in moderation.

Alc0h0l addiction is a slippery slope that can lead to pancreatitis, liver failure and worse. There are also links to dementia and Alzheimer’s. Drinking alcohol has massive health implications that are hard, if not impossible to reverse.